East Coast fever (ECF) is a lethal cattle disease produced by the infection of the apicomplexan parasite Theileria parva. The existing vaccine (ITM) against ECF has several limitations: difficult to produce, expensive, needs cold chain, expertise for delivery, animals become carriers, risk of introduction of new parasite variants in the field. Sub-unit vaccines based on non-infectious parts of the parasite Theileria parva can solve all the above problems. p67C is a very promising vaccine antigen, but it’s weak.