Identification of virulence factors as novel vaccine targets for contagious bovine pleuropneumonia by whole genome saturated mutagenesis




• CBPP is characterized by immunopathology, i.e. dysregulation of the host’s immune response.

• In vitro data indicates that this dysregulation begins at the very early stages of infection, at the initial site of bacteria-host cell interaction in the


• We aim towards identifying vaccine candidates that can disrupt the bacteria-induced dysregulation of the host’s immune response.


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